P53 Gain-of-Function: Tumor Biology and Bioinformatics Come Together
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چکیده
منابع مشابه
Genomics and Biology Come Together to Fight HIV
Primer A lthough the genomic sciences emerged from squarely within the biological sciences, genomics and biology often now seem almost strangers. Nowhere is this divide more striking, or more unfortunate, than in studies of the genetics of complex traits such as common human diseases. For many years, attempts at understanding the genetics of common diseases languished in candidate gene studies ...
متن کاملGain-of-function mutations in the tumor suppressor gene p53.
The tumor suppressor protein p53 is a multifunctional transcription factor involved in the control of cell cycle progression, DNA integrity, and cell survival. p53 is mutated in half of all tumors and has a wide spectrum of mutation types. p53 mutants show different degrees of dominance over coexpressed wild-type p53, and loss of the wild-type p53 allele has been observed frequently. Several p5...
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sors. Unfortunately, the cytokine appears not to influ-traction, hydrogen bonding, hydrophobic packing, and shape and charge complemetarity, have been known to ence B lymphopoiesis in humans and no factor with be important in protein-protein interactions for decades. comparable function has been found. There are also Other, less ubiquitous and more evasive, factors, such dramatic species differ...
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A main concept in the use of grids for distributed computing or shared data management is the concept of visualization, that means user visualization and of course resource visualization. A single user should work on the shared resources of a grid without worrying about having a user accounts on all the different machines evolved in his calculation or data search process. This virtualization of...
متن کاملCome together, right now
A main concept in the use of grids for distributed computing or shared data management is the concept of visualization, that means user visualization and of course resource visualization. A single user should work on the shared resources of a grid without worrying about having a user accounts on all the different machines evolved in his calculation or data search process. This virtualization of...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2005
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.4.5.1691